Common allergic drugs can damage testicular function

It can contribute to antihistamines, which are usually available at the table and used to treat allergies, in male infertility, according to the results of a review of a new methodology.
Description of antihistamines
The researchers found that antihistamines inhibit testicular function in male rats.
The authors of the new paper argue that more studies are needed to examine this association, and suggest that people be warned of the excessive use of these drugs.

Dr. Carolina Mondello, author of the study, reported her findings in the journal Reproduction.

Histamine is a molecule produced by the body when the immune system is activated by the perceived threat.

Histamine tries to eliminate allergens from the body by causing sneezing, itching or making the eyes fill with water.

This is part of the standard defense of the organ system – but in some people, they exaggerate the immune system in response to allergens such as pollen, pet dander, or dust, and call for histamine to create excessive sneezing or irritation of the body. eye, as is the case with hay fever. .

Antihistamines are the most common medications to reduce these symptoms. However, in addition to working on histamine, it was found that antihistamines also affect other areas of health, which creates undesirable side effects associated with sleep behavior and sexual function and fertility.

Because allergies are becoming more common in industrialized countries, it also increases the use of antihistamines, so it is important that scientists and doctors better understand any associated with these drugs do not need a prescription side effects.

Antihistamines reduce the quality of sperm
The researchers carried out, from the Institute of Experimental Biology in Buenos Aires, Argentina, a systematic review of studies conducted on animals that examined the relationship between histamine and fertility. They analyzed the small and large studies conducted in the last four decades.

The review found that many studies reported a relationship between the use of antihistamines in male animals and testicular dysfunction.

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The authors of the study suggest that antihistamines seem to interfere with the production of sex hormones in the testes, leading to sperm, sperm or poor, or low-lying, sperm count.

It is important to bear in mind that all the studies studied by Dr. Mondello and his colleagues have been carried out on animals. Studies in humans that see the relationship between the use of antihistamines and male fertility are limited, so it is difficult to generalize these results to humans.

More studies are needed
More research will be needed before the mechanisms underlying this link can be fully understood.

“More comprehensive tests are needed to evaluate the possible adverse effects of antihistamines on reproductive and sexual health,” says Dr. Mundillo. “This can lead to the development of new treatments to alleviate allergy symptoms without compromising fertility.”

Researchers say they will now begin to assess how histamine affects testicular tumors.

In previous studies, some other common drugs associated with infertility in men, such as calcium channel blockers and tricyclic antidepressants and anabolic steroids.

Last year, we published an advantage on how infertility affects men. In that article, we analyzed how some simple lifestyle advice helps reduce the risk of male infertility.

This included eating healthy, maintaining the proper weight, reducing stress and physical activity. We also recommend reducing smoking, reducing alcohol consumption and avoiding tight underwear.

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