Viagra can reduce the risk of colorectal cancer by half

According to new research published in the journal Cancer Prevention Research, a small dose of Viagra to treat erectile dysfunction, when taken daily, can significantly reduce the risk of colon cancer.
Viagra tablet
A small daily dose of erectile dysfunction medication can be very valuable in treating and treating colorectal cancer.
The American Cancer Society (ACS) reports that colorectal cancer is the third leading cause of death from cancer in men and women in the United States.

It is the third most common form of cancer: one in 22 men and 1 in 24 women can develop it at some time.

An important risk factor for the development of the disease is a mutation in a gene called polyposis coli (APC), a tumor suppressor. People with a genetic mutation of APC can develop into hundreds of colorectal tumors, which can eventually lead to cancer.

A new research uses the mouse model of this genetic mutation to evaluate the effect of sildenafil, marketed as a popular Viagra drug for the treatment of erectile dysfunction, on the risk of colorectal cancer.

The study, conducted by Dr. Darren Browning, a cancer researcher at the Georgia Cancer Center and the Department of Biochemistry and Molecular Biology, University of Augusta, Georgia, states that a small daily dose of the drug can reduce the number of colorectal tumors . Half

The researchers added sildenafil to the drinking water of mice that were genetically modified to develop hundreds of benign tumors, which in humans almost always lead to colorectal cancer.

Useful mechanism of Viagra
The study found that sildenafil increases the levels of a substance called “monosaccharide globulin” (cGMP), a calcium regulator within cells.

CGMP contributes to the good physiological performance of smooth muscle cells, pituitary cells, retinal cells and others.

As Dr. Browning and his colleagues have shown in their study, it has been shown that cGMP regulates the accumulation of intestinal epithelium, or the cell layer within the intestine, that forms a physical barrier against foreign substances and bacteria.

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The epithelium plays a key role in the way our immune system responds to these strange factors, and in cases such as inflammatory bowel disease, epithelial inflammation.

In their study, Dr. Browning and the Cindinafil group studied cGMP because they knew that sildenafil inhibits another substance that has the potential to increase cGMP.

This substance is called phosphodiesterase-5, an enzyme that occurs naturally in colon cells, and in other cases. The cGMP enzyme can collapse, which makes it more available to create cells that form the protective layer that is the epithelium.

Viagra reduces cancerous tumors by 50 percent
The study revealed that Viagra increased cGMP, which in turn, suppressed some cells that proliferated in the gastrointestinal tract.

The second beneficial effect of cGMP enhanced by Viagra was that it aided the normal process of abnormal cell death and elimination.

“When we administer Viagra,” Dr. Browning explains, “we reduce the entire area of ​​our body that deals directly with everything we put into our mouths, and we generally deal with high cell turnover.”

“The active cells are more susceptible to the mutations that cause cancer,” he explains.

In the rat model, small doses of Viagra reduced the formation of benign tumors by 50 percent. “Administering a [small] dose of Viagra can reduce the number of tumors in these animals by half,” said Dr. Browning.

He adds that the next steps should include human clinical trials of already approved drugs, with a focus on people already at risk for colorectal cancer.

Dr. Browning notes that Viagra is unlikely to cause such side effects in such small doses.

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